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With the Met allele, your brain has less capacity to form new neural pathways, making it harder to respond to antidepressants, therapy, and mood-lifting interventions. You might experience persistent low mood, lack of motivation, brain fog, and difficulty feeling pleasure. If you have the slow variant, your brain takes far longer to clear stress hormones after a trigger, leaving you in a state of heightened reactivity and vigilance. COMT is the cleanup crew for stress hormones in your brain. These genes code for the enzymes and proteins that build, release, recycle, and clear the neurotransmitters your brain uses to regulate mood, emotional resilience, and stress recovery.